Ottawa to Wyandot to Iroquois fur trade flourishes, supported by Wyandot agricultural surplus.
March 16; 1,200 well-armed Iroquois launch coordinated attacks into Ouendake, wiping out the mission towns of St. Ossossane is abandoned as the Huron Confederacy disintegrates. In December, the Petun lose their principal town to the Iroquois.
Already at war with other Iroquoian tribes, the Wyandots begin to move west.1541 - May 8; Soto reaches the Mississippi River, having marched overland from the Floridas.
The brutal behavior of the Spanish has a devastating effect on the tribes of the southeast; perhaps coincidently, Mississippian culture enters a rapid decline.c.
Petun and Huron refugees leave Ontario, and spend the winter of 1649-50 on Mackinac Island.c.
1650 - First French contact with the Shawnee in Tennessee, where they have drifted from Ohio. The Five Nations temporarily control all the lands on either side of Lake Erie and Lake Ontario.1673 - In May, Father Marquette and Louis Joliet set out from St.