He and Stewie are often at the center of the show's most critically acclaimed episodes, most notably the "Road to..." episodes, where he and Stewie go on road-trips together.
Brian is portrayed as an intellectual—a Brown University attendee—who often serves as the family's voice of reason, pointing out how ridiculous Peter's ideas are.
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Christopher Cross "Chris" Griffin (voiced by Seth Green) is the Griffins' 16-year-old son and middle child who, like Meg, is a teenager.
He is friendly, idealistic, funny, and good-hearted.
Megan "Meg" Griffin (voiced by Lacey Chabert in season 1, Mila Kunis since season 2) is the Griffins' 18-year-old daughter and oldest child.
She is a self-conscious, unattractive, sensitive, and emotionally fragile teenager who is more often than not ridiculed and ignored by the people around her.